Thank you all for your helpful replies!
I am running full sythetics throughout, Michelin 265-75R-16 LTX/MS (recalibrated to non-stock tire size by SuperChips) w/ 55psi front and rear, just aligned, with empty bed. I start slow and look ahead to minimize using brakes by easing up on throttle when distant light is amber or red. I occassionally use Tow Haul to slow the vehicle - it increases rpm but at no cost to fuel consumption (I think) Camper shell or open bed I get the same mpg. I guess the most useful thing is to drive slower! - but in Atlanta area you get run over under 70!
Thanks again friends!