Here is a reasonably scientific test - for illustration's sake:
1) Take two brand new, identically equipped Duramaxes off the assembly line, one that will run treated #2, the other to run only 'plain' #2 as a control;
2) We then take 50 Duramax owners (members of TDP perhaps), have them take each truck home for a week of varied driving, cold starts, etc., and after using both trucks - record the one that they believe was running treated fuel;
Hypothesis #1: ~25 would pick truck 'A', and ~25 would pick truck 'B' +/- 5%.
Hypothesis #2: The truck running treated fuel would average slighly better MPG over the entire test period, but its total fuel + additives bill would be higher than the truck running only straight #2, when adjusted for any variance in miles driven between both trucks.
Hypothesis #3: The truck running treated fuel, if these tests were extended to include (500 drivers * 2000 miles) = 100K miles, would be less likely to develop a 'stuck' injector, or encounter injector failure, while the control truck would be more likely to encounter decreased mileage at some point, or even stuck/failed injector(s).
Again, even with a control - its easy to see that BIG variances in driving by the 50 or 500 members, temperatures, terrain, and countless other factors would make an accurate, scientific test difficult if not impossible. With only one truck, its nearly impossible for any individual to make any scientifically sound conclusions - as there is no way to test against an accurate control...